Publication Date:
2014
abstract:
The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2(TRFH) binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance.
Iris type:
01.01 Articolo in rivista
Keywords:
shelterin protein; TRF2
List of contributors:
DE LUCA, Viviana; Capasso, Clemente
Published in: