Immunocytochemistry as a tool in the study of neurotransmitter actions

Protein phosphorylation mediated by second messengers appears to be an important general mechanism by which neurotransmitters accomplish some of their effects on target neurons. In recent years several protein kinases and a variety of phosphoproteins have been identified in mammalian brain. However, the physiological function of the large majority of protein phosphorylation reactions occurring in nerve cells is still poorly understood. This review summarizes how immunocytochemistry can be important in relating biochemical information to specific cellular functions. © 1984.