Light scattering as spectroscopic tool for the study of disperse systems useful in pharmaceutical sciences

The use of colloidal systems in pharmaceutical formulations, for addressing the issue of selective and controlled drug delivery or for improving drug availability, requires an accurate previous characterization of their chemical and physical properties. Light scattering is a useful and non-invasive method to study the structure and conformation of colloids in a wide space-scale, encompassing nanometric- to micrometric-sized particles, as well as their size distribution, surface electrostatic potential and aggregation phenomena occurring under proper conditions. In this review the physical bases of the light scattering approach are described and many examples are reported to discuss the examination of various multiphase systems useful in pharmaceutical fields.