The susceptibility CDKN2 locus may have a role on prognosis of melanoma patients

Toward the characterization of a genetic profile with prognostic value, the CDKN2 locus at chromosome 9p21, harboring the CDKN2A and CDKN2B genes, may represent the main candidate genomic region to be investigated in melanoma. To determine whether a genotype of single- nucleotide polymorphisms (SNPs) within the CDKN2 locus may correlate with the melanoma outcome, we analyzed nine SNPs jointly by logistic regression among 396 melanoma patients and 383 healthy controls originating from south Italy.