A New Ratiometric Lysosomal Copper(II) Fluorescent Probe To Map a Dynamic Metallome in Live Cells
Academic Article
Publication Date:
2018
abstract:
We synthesized a new ratiometric fluorescent Cu2+ probe, bearing a morpholine moiety for selective binding to lysosomes and two picolylamine arms for the specific chelation of divalent copper ions. The probe capability to detect lysosomal Cu2+ was demonstrated in human differentiated neuroblastoma cells by confocal microscopy.
Iris type:
01.01 Articolo in rivista
Keywords:
Alzheimer's Disease; copper sensor; Lisosome
List of contributors:
Rizzarelli, Enrico; Copani, AGATA GRAZIELLA; Giuffrida, MARIA LAURA; Zimbone, Stefania
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