Carcinoembryonic antigen concentrations in patients with acute coronary syndrome

Carcinoembryonic antigen (CEA), one of the most widely used tumor markers, has been recently associated with carotid atherosclerosis. The aim of our study was to evaluate whether CEA concentrations have a role in coronary artery disease (CAD). METHODS: Serum CEA concentrations were evaluated in 89 patients, including 50 patients with acute coronary syndrome (ACS) (Group I, 44 with acute myocardial infarction, six with unstable angina, 38 males, 65 ± 2 years) and 39 patients with stable CAD (Group II, 33 males, 66 ± 3 years). In addition, 33 subjects (16 males, 62 ± 2 years) were also included as a control group (Group III). RESULTS: ACS was significantly associated with increased mean CEA concentrations (3.1 ± 0.3 vs. 1.75 ± 0.1 and 1.7 ± 0.2 ng/mL in Groups I, II and III, respectively, p < 0.001). Increased CEA concentrations remained an independent determinant for ACS (OR=3.1, 95% CI=1.2-7.9, p < 0.05) after correcting for other significant risk factors. CONCLUSIONS: CEA might represent a potential new candidate biomarker for the prediction of risk associated with ACS.