EFFECT OF 5-AZACYTIDINE (5-AZAC) ON THE INDUCTION OF CHROMATID ABERRATIONS (CA) AND SISTER-CHROMATID EXCHANGES (SCE)

Academic Article
Publication Date:
1985
abstract:
Experiments were carried out using human lymphocytes from a male donor in order to test the action of 5-azaC treatment on the induction of SCE and chromatid aberrations. The 5-azaC was found to increase the frequency of both baseline and MMC-induced SCEs. Using the same 5-azaC treatment conditions it was found that the frequency of X-ray-induced CA did not increase.
Iris type:
01.01 Articolo in rivista
Keywords:
DNA methylation; 5-aza-cytfone; DNA recombination; sister chromatid exchange
List of contributors:
Handle:
https://iris.cnr.it/handle/20.500.14243/442647
Published in:
MUTATION RESEARCH. FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Journal