Chemical composition, safety and efficacy of Pistacia vera L. oleoresin essential oils in experimental wounds

The aims of the study were to evaluate the wound-healing properties in an in-vivo model of the essential oils from Algerian and Italian Pistacia vera L. oleoresins. The essential oils (EOs) were obtained by hydrodistillation of oleoresins from the trunk of plants. They were analyzed by GC-FID and GC-MS, ?-pinene was the main constituent of both EOs. The wound-healing potential of P. vera EOs was investigated using an excision wound model in rabbits. The EOs were mixed with petroleum jelly to obtain a topical ointment with a final concentration of 5%. The percentage of the evolution of wound contraction was calculated and histological sections of tissues were examined. Both preparations possess wound-healing activities comparable to that of the reference drug Cicatryl-Bio. Some EOs exhibit a wound-healing potential suggesting that they could find a place in modern therapy.