Transcription Factor Driven Gene Regulation in COVID-19 Patients

Simple Summary: The present work aims to shed light on the role that Transcription Factors (TFs) play in the alteration of gene expression and regulation driven by COVID-19 infection. In this regard, 19 human transcription factors were selected, since they are predicted to target and potentially regulate human proteins interacting with Spike glycoprotein of SARS-CoV-2. Thirty-one human genes, predicted as targets of these TFs, were selected since they showed statistically significant differences in their correlation values with respect to TFs between healthy and COVID-19 patients. It can be hypothesised that they are major players in the alteration of the regulation pattern driven by COVID-19. In this light, together with the 19 identified TFs, the 31 human genes be considered as potential targets to counteract COVID-19 infection.