Minor bioactive polyacetylenes from Petrosia ficiformis

Six novel minor polyacetylenic metabolites were isolated from the marine sponge Petrosia ficiformis by means of bioassay-directed purification. Spectral analysis led to partial structure determination, and the brine shrimp lethality assay on the pure compounds allowed a structur/activity relationship study. The potato disc antitumor assay and tests for the inhibition of fertilized sea urchin eggs were also conducted on the most abundant compounds