Asymmetric oxidation of 1,3-cyclohexadiene catalysed by chloroperoxidase from Caldariomyces fumago

Chloroperoxidase from Caldariomyces fumago catalyses the oxidation of prochiral 1,3-cyclohexadiene using TBHP as terminal oxidant. The process occurs enantioselectively and furnishes the non-racemic trans diols 1,2- and 1,4-dihydroxycyclohexene, (-)-3 and (+)-4, in good ee and yield.