Bicyclo[2.2.2] octane analogues of patchouli alcohol by Sakurai reaction and Nagata cyclization. Synthesis and olfactory properties of novel isopropyl derivatives
Academic Article
Publication Date:
2008
abstract:
The synthesis of bicyclo[2.2.2]octane patchouli alcohol analogues by the Sakurai conjugate addition and Nagata cyclization is described. By this approach, complementary to those so far adopted and based on the Diels-Alder addition, known analogues 2, 3 and 20 and new analogues 8-11, with 1-isopropylbicyclo[2.2.2] octane structure, could be obtained. The olfactory properties of 8 and 10 were also evaluated.
Iris type:
01.01 Articolo in rivista
Keywords:
1-isopropylbicyclo[2.2.2]octane derivatives; synthesis; Sakurai allylation; Nagata cyclization; patchouli alcohol analogues; olfactory properties
List of contributors:
Ceccacci, Francesca
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