A convenient microwave-assisted synthesis of N-glycosyl amino acids

Academic Article
Publication Date:
2007
abstract:
Optimization of coupling reactions of glycosylamines with Fmoc-protected aspartic acid, by microwave approach, is described. Different reaction conditions, quantities of substrates and solvents were tested to develop simple and reproducible methodologies. The best results were obtained using new triazine-based coupling reagents with a monomode microwave Discover BenchMate instrument (CEM). The N-glycosyl amino acids were then deprotected to achieve final products for SPPS.
Iris type:
01.01 Articolo in rivista
Keywords:
Microwave-assisted synthesis; N-Glycosyl amino acids; Synthetic glycopeptide probe; Coupling reagent; Solid-phase peptide synthesis
List of contributors:
Handle:
https://iris.cnr.it/handle/20.500.14243/453159
Published in:
TETRAHEDRON LETTERS
Journal