Early Altered Cells Health Status Detection via Label Free Impedance and Broadband dielectric Spectroscopy

Human cells are able to respond to applied electrical signals and their response is different according to cell health status. In this framework, the electrical bio-impedance can be sensitive tools to monitor cellular health status in addition to other commonly adopted biological methods. Here we show that in vitro cellular lines affected by inflammatory processes or outside insult can be identified by using impedance and broadband dielectric spectroscopy analysis. The analysis of specific parameters of the electrical response evidences modification in the cells compartments. The features of the cell electrical response allow to discriminate between the different processes involved.