Mycalol, a natural lipid with promising cytotoxic properties against human Anaplastic Thyroid Carcinoma cells

Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high-mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid (1) that showed important and selective cytotoxicity against ATC-derived tumor cell lines.