Mycalol, a natural lipid with promising cytotoxic properties against human Anaplastic Thyroid Carcinoma cells
Academic Article
Publication Date:
2013
abstract:
Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high-mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid (1) that showed important and selective cytotoxicity against ATC-derived tumor cell lines.
Iris type:
01.01 Articolo in rivista
Keywords:
configuration determination; cytotoxicity; lipids; natural products; NMR spectroscopy; mycalol; ATC cells; Antarctic
List of contributors:
Fontana, Angelo; Fusco, Alfredo; Cutignano, Adele; Nuzzo, Genoveffa
Published in: