Helicobacter pylori and coronary heart disease: Which directions for future studies?

Classical risk factors explain the pathogenesis of coronary heart disease (CHD) in only a proportion of cases; therefore, the need to investigate the possible role of "new" agents has incited intense research. Since 1994, a number of studies regarding the possible involvement of Helicobacter pylori (H. pylori) have been published with conflicting results. Establishing a causal link between this infection and CHD would be of major public health importance, since the eradication of the bacterium is easy and much less expensive than long-term treatment of the other risk factors.