Artificial diiron proteins: From structure to function.

De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. Here, the authors summarize the design, structure detn., and functional properties of a family of artificial diiron proteins which include DF1, DF2, DF2t, and DFsc.