Analysis of the interaction of trichodiene synthase 5 (TRI5) with natural and natural-like inhibitors of trichothecene biosyntesis

The fungal pathogen Fusarium culmorum causes Fusarium head blight (FHB) on cereals resulting in yield loss and contamination of grain with type B trichotecene mycotoxins such as deoxynivalenol (DON), and its acetylated derivatives. A key step in the synthesis of trichothecenes is catalyzed by the trichodiene synthase 5 (TRI5) that converts farnesyl pyrophosphate to trichodiene.