Publication Date:
2017
abstract:
MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.
Iris type:
02.01 Contributo in volume (Capitolo o Saggio)
Keywords:
Comorbidities; Data integration; microRNA; Regulatory network; Systems biology; Target prediction
List of contributors:
Pellegrini, Marco
Book title:
MicroRNA Detection and Target Identification