Improvement of the synthesis of immunologic carbohydrate vaccines containing the tumor associated antigen CaMBr1
Academic Article
Publication Date:
2001
abstract:
The simplified synthesis of a portion of Globo-H hexasaccharide, a saccharide antigen overexpressed by breast cancer cells, and its conjugation to two different immunogenic proteins are described. The conjugated vaccines, evaluated in a preclinical model, showed good immunogenic potential.
Iris type:
01.01 Articolo in rivista
Keywords:
carbohydrates; conjugate vaccine; CRM197; globo-H; KLH
List of contributors:
Prosperi, Davide
Published in: