Magnetic targeting on heart tissues: modelling of magnetic forces

The successful use of nanoparticles in therapeutic applications has recently prompted scientists to look for effective strategies to focus them in specific organs. Among these methods, magnetic targeting consists in the use of magnets or coils capable of producing high-gradient magnetic fields (and therefore magnetic forces) on the magnetic nanoparticles, thus increasing their concentration in the target. Although some experimental studies have shown the effectiveness of this technique, there are still few studies able to quantify and to explain the experimental results. To this purpose, in this study, the behavior of various magnetic targeting systems, optimized on the anatomy of different anatomical human models, was evaluated by means of computational electromagnetism techniques.