Synthesis, chemical and rheological characterisation of new hyaluronic based hydrogels

New hyaluronic acid-based hydrogels have been synthesized. The carboxylate groups of hyaluronan were activated in order to bind the amino terminal groups of the di-amine cross-linking reagent. Different hydrogels were obtained according to different di-amine cross-linking agents. The cross-linked polymer (C.L. Hyals) by a heterogeneous reactin using sulphur trioxide pyridine complex (SO3-Py). The thermomechanical properties and swelling properties were evaluated and discussed in relation to the chemical structure. of the gels