Synthesis, in vitro and in vivo evaluation of new 99mTc-labeled cyclic RGDfK peptide monocationic complexes

Synthetic peptidesrepresent first choice biomolecules, with respect to proteins and mAb, for the monitoring of population variability and receptor functionality associated to a tumor pathology due to their favorable pharmacokinetic profile. It as been demonstrated thet the surface molecule integrin alfa-V beta-3 could be an ideal target for the interaction with melanoma directed radiolabeled peptides......