YeastpRofileSpearman: A software to compute cross-correlation profiles around TSS and TTS of yeast mRNAs

YeastpRofileSpearman is a portable Windows form application, written in C#, to compute the profile of a genomic variable around transcription start (TSS) and termination (TTS) sites of yeast mRNAs. It is variation of the software application YeastpRofile (https://sourceforge.net/projects/yeastprofile/) in which Spearman's rank correlation coefficient (Rs) is computed in place of Pearson correlation coefficient. The profile is obtained by calculating the genome-wide Rs between the genomic variable values and the TSS (or TTS) counts at incremental shifting of transcribed strand. The data of TSS and TTS counts used to compute the cross-correlation profiles were taken from the work of Pelechano et al. (1). The input file must be a BedGraph formatted file based on yeast genome sequence release R64. The output file is a text tab-delimited table reporting Rs values for the various shifts of variable coordinates with respect to TSS or TTS. 1) V. Pelechano et al., Nature, 497 (2013) 127-13.