Stereoselective synthesis of a functionalized 2-oxo-1-azabicyclo[5.3.0]alkane as a potential scaffold for targeted chemotherapy strategieseted chemoterapy strategies

A stereoselective synthesis of functionalized 2-oxo-1-azabicyclo[5.3.0]alkane is presented. Key events of the synthetic sequence were the stereoselective propenylation of an N-acyliminium ion and a ring-closing metathesis reaction forming a 7-membered lactam.