Bifunctional Cinchona Alkaloid/Thiourea Catalyzes Direct and Enantioselective Vinylogous Michael Addition of 3-Alkylidene Oxindoles to Nitroolefins

Articolo

Data di Pubblicazione:

2012

Abstract:

Vinylogy: Advances in asymmetric catalysis using the bifunctional cinchona alkaloid/thioureas enabled an umpolung of the classical Cb reactivity of 3-alkylidene oxindoles, thus allowing the development of the first and sole example of a direct, organocatalytic asymmetric vinylogous Michael (AVM) reaction with nitroolefins

Tipologia CRIS:

01.01 Articolo in rivista

Keywords:

asymmetric synthesis; heterocycles; Michael reaction; organocatalysis; umpolung

Elenco autori: