Ti(O-iPr)4 promoted regio- and stereoselective aminolysis of 2,3-epoxy amides

A new, mild and cheap aminolysis of 2,3-epoxy amides Ti(O-iPr)4 mediated has been developed. The reaction proceeds with excellent regioselectivity, regardless of the steric hindrance of the substituents on the heterocyclic ring, providing vicinal amino alcohols very suitable for synthetic applications.