Structural Features of Model Glycopeptides in Solution and in Membrane Phase: a Spectroscopic and Molecular Mechanics Investigation

Model glycopeptides of the general formula Boc-Ala-Thr(G-D)-A1-A2-Leu-Leu- Lys(N)-Ala-OMe [Boc = tert-butoxycarbonyl, D = dansyl (di-Me aminonaphthalenesulfonyl), G = glucosyl, N = naphthyl, A1, A2 = Ala-Leu or Aib-Aib (denoted D-G-Ala-N and D-G-Aib-N, resp.)] were used to investigate glycoprotein-membrane interactions