Stereoselective synthesis of (R)-(-)-2,2-dimethyl-3-t-butoxycarbonyl-4-ethynyl-oxazolidine: a chiral building block for the synthesis of a new class of substituted alkynes

(R)-(-)-2,2-Dimethyl-3-t-butoxycarbonyl-4-ethynyl-oxazolidine (3a) has been prepared in good yield from chiral aminoaldehyde (4) through a two step procedure. Metalation of compound (3a) and subsequent reaction with electrophiles has been investigated leading to the stereoselective synthesis of a new series of substituted alkynes which can be considered us useful precursors of compounds of biological interest