Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions

Liraglutide is a long-acting glucagonlike peptide (GLP)-1 analog, which exerts its glucose-lowering action through multiple mechanisms (1). One important feature of liraglutide is its ability to enhance -cell function. The effects on -cell function have been demonstrated using standardized -cell function tests based on intravenous glucose administration (2- 4). However, these studies may not reflect the modes of action of liraglutide during normal living. To assess the effects of liraglutide on -cell function in normal living, we have used a validated -cell model to analyze 24-h triple-meal experiments