A tissue engineering strategy using placental mesenchymal stem cells hosted on RKKP glass-ceramic for bone regenerative medicine applications

In tissue engineering protocols, the survival of transplanted stem cells is a limiting factor that could be overcome using a cell delivery matrix able to support cell proliferation and differentiation. With this aim, using human amniotic mesenchymal stromal stem cells (hAMSCs) from placenta, the cell-friendly and biocompatible behavior of RKKP glass-ceramic coated Titanium (Ti) surface was studied. The glass-ceramic material was prepared by sol-gel synthesis procedure and then deposited onto the Ti surface by Pulsed Laser Deposition method. Our findings demonstrated that the RKKP coated Ti supports are cell-friendly substrates and the combination of the hAMSCs' properties together with the bioactive characteristics of RKKP glass-ceramics may be used as a new potential tool for bone tissue engineering and regenerative medicine applications