THROMBOLYTIC ACTIVITY OF DEFIBROTIDE A MORPHOMETRIC EVALUATION IN EXPERIMENTAL VENOUS THROMBOSIS

We have studied the morphometric aspects of the thrombolytic activity of Defibrotide in experimental venous thrombosis induced by inserting a collagen-coated nylon thread into the femoral vein of rabbits. 24 hours after thrombus induction Defibrotide decreases the size of thrombi by a factor of 6; stimulation of fibrionolysis and inhibition of platelet and leucocyte recruitment are prominent. Size of the thrombus, extension of the fibrin net and platelet adhesion are also modified by Defibrotide in 7-day-old thrombi where graulation tissue has replaced the original coagulum.