Specifically designed polymeric nanospheres increase cellular uptake of unmodified antisense ODNs
Academic Article
Publication Date:
1999
abstract:
The cellular uptake and the inhibitory effect of c-myb unmodified antisense oligonucleotides reversibly bound to new polymeric nanoparticles in HL-60 cellular system have been found to increase by 50 folds if compared with the free ODN. An initial single dose (320 nM) of the nanoparticle bound unmodified antimyb ODN has been able to specifically inhibit HL-60 leukemia cell proliferation for at least 8 days.
Iris type:
01.01 Articolo in rivista
List of contributors:
Tondelli, Luisa
Published in: