Coronary microcirculatory vasoconstriction induced by low- flow ischemia in mouse hearts is reversed by an A2A adenosine receptor agonist

Coronary microcirculatory vasoconstriction was observed during ischemia in patients with severe coronary stenosis. This event can be mimicked experimentally by lowering the coronary perfusion pressure (CPP) and is attenuated by adenosine. To determine if the selective A2A agonist, regadenoson, could modify this response, coronary vascular resistance (CVR) was monitored for 70 min in isolated mouse hearts (Langendorff configuration) using two protocols.