Methionine challenge paradoxically induces a greater activation of the antioxidant defence in subjects with hyper- vs normohomocysteinemia

To determine whether chronic hyperhomocysteinemia induced post-methionine loading (PML) is associated with different response in the aminothiol redox state and oxidative stress versus normohomocysteinemia post-methionine loading (PML) , we assessed PML plasma thiols, vitamins, free malondialdehyde (MDA), and blood reduced glutathione (GSH) in 120 consecutive subjects (50 [35-56] years, 83 males), divided into two groups according to PML plasma total Hcy : 35 µM (Group 1, n