Enzyme-mediated synthesis of new 1,3-dioxane-odorants related to Floropal (R).

The enzyme-mediated synthesis of enantiomerically enriched 1,3-dioxane odorants analogous to Floropal(R) is here described. The complete olfactory evaluation of each sample is also reported. The addition of a single methyl group at C-5 of the dioxane ring of Floropal(R) modifies the elicited odour sensation, still preserving a pleasant character. The substitution of the methyl group at C-6 with just an ethyl moiety completely changes the odour profile of the molecule. Even subtler are the odour differences generated by configurational variations.