Preparation of the Enantiomerically Enriched Isomers of the Odorous Cyclic Ethers Clarycet®, Florol®, and Rhubafuran® by Enzymatic Catalysis.

All the enantiomerically enriched stereoisomers of Clarycet(R) (1), Florol(R) (2), and Rhubafuran(R) (3) were prepared by biocatalysis routes. Their absolute configurations were established, and their olfactory properties were fully evaluated.