High-field 3 T imaging of Alzheimer disease

Alzheimer disease (AD) is a neurodegenerative disease with neuronal loss, leading to dementia and neurological impairment [1]. Metabolic alterations are the basis of histological changes, occurring several years before cognitive impairment. In mild cognitive impairment (MCI) functional disability is absent; conversely, in Alzheimer dementia, disease progression is faster and disability occurs. © 2006 Springer-Verlag Berlin Heidelberg.