CYTOGENETIC ABNORMALITIES IN POST-POLYCYTHEMIA VERA AND POST-ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS: CORRELATIONS WITH GENOTYPE AND PHENOTYPE IN THE MYSEC STUDY

Summary: Abnormal karyotype was found in 34.1% of SMF patients and is over- represented in post-PV MF. No different distribution was detected among genotypes. Abnormal karyotype was associated with lower platelet count, larger splenomegaly, higher circulating blasts, consti- tutional symptoms and inferior survival. Among subtypes, MK re- mained the most powerful predictor of outcome.