Parallel, Stereoselective Syntheses of both Enantiomers of Muricatacin and Their Sulfur and Nitrogen Relatives Using the Silyloxy Diene-Based Methodology

The synthesis of both enantiomers of muricatacin, (R,R)- and (S,S)-1a,5,6 and their sulfur and nitrogen relatives, (R,R)- and (S,S)-1b and (R,R)- and (S,S)-1c has been performed moving from the silyloxy dienes according to a chemically uniformed reaction protocol, using both enantiomers of glyceraldehyde acetonide [(R)- and (S)-2] as the chiral sources.