Publication Date:
2005
abstract:
Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cisdiltiazem
with configuration (2S,3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support)
were tested. The best separation of DTZ from A, B, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The
characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS.
Iris type:
01.01 Articolo in rivista
Keywords:
HPLC; LC-MS; liquid chromatography-mass spectrometry; drugs; diltiazem
List of contributors:
Fanali, Salvatore
Published in: