miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: a systematic review

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine turner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases using the keywords "miR-221" AND the "specific keywords" related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and weight of deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.