NUSAP1 (nucleolar and spindle associated protein 1)

NUSAP1 (Nucleolar and Spindle Associated Protein 1) is a cell-cycle dependent protein highly expressed during mitosis. It has microtubule-binding and DNA-binding activity, which underlies its best-characterised function as a regulator of the mitotic apparatus in dividing cells. Deregulated abundance of NUSAP1 is associated with misassembly or misfunction of the mitotic spindle during mitosis, originating genetic instability in daughter cells. Roles in cell migration, invasion and metastases are also reported, as well as functional interactions with pro-oncogenic pathways. NUSAP1 is overexpressed in several cancer types and is regarded as a novel prognostic biomarker. Experimental down-regulation of NUSAP1 abundance often inhibited cell proliferation in several cancer contexts. NUSAP1 is also proposed as a therapeutic target, with the potential to improve the outcome of treatments in combination therapy for certain cancer types.