A Grid-based SPM service (GriSPM) for SPECT and PET neurological studies.

Statistical parametric mapping (SPM) for the in-vivo assessment of brain functional parameters in neurological diseases is a voxel-based methodology used within the nuclear medicine community to increase the confidence level of diagnostic reporting. SPECT/PET SPM measurements result in maps of statistically significant hypo-/ hyperfunctionality in cerebral regions of the patient with respect to normal controls [1]. In general, voxel-based assessments of changes in the functional signal allow earlier and better diagnosis of neurological pathologies, which are also less biased than qualitative visual inspection of images or quantitative region-of-interest analysis