Impiego dei liposomi in elettroforesi capillare come additivi delle soluzioni elettrolitiche e come pseudo-fase Stazionaria in sospensione

This brief report describes the results of our recent studies carried out to evaluate the use of liposomes in capillary electrophoresis of peptides and proteins, acting as additive or as a dispensed pseudo-stationary phase with the capability of improving efficiency, selectivity and resolution. The report describes the results of our studies conducted with unilamellar liposome suspensions consisting of the phospholipid 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine (POPC), which is prepared by an extrusion technique. The report describes the different strategies that have been employed for allowing the liposomes to act as a pseudo-stationary phase with the ability of modulating selectivity, resolution and separation performance of peptides and proteins in bare fused silica capillaries.