The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases.

Currently, the most widespread global ailment is not COVID-19 or any 2 other such devastating infectious diseases. In fact, obesity has been recognized 3 as a prime risk in the development of cardiometabolic diseases (CMD), neurode- 4 generative diseases (NDD) and cancer and their morbidity and mortality signa- 5 ture. The pathobiology and therapy of obesity and related diseases are immensely 6 complex at the cellular and molecular levels. This scenario raises the question of 7 how such a complexity may be grappled in a more tangible manner. Since 2003, 8 we have been thinking "what nobody has yet thought about that which everybody 9 sees", namely, metabotrophic factors (MTF or metabotrophins, metabokines). They 10 include mainly (i) the neurotrophins nerve growth factor (NGF) and brain-derived 11 neurotrophic factor (BDNF), and (ii) the adipomyokines adiponectin, irisin, BDNF, 12 fibroblast growth factor-21 alike as adipose- and skeletal muscle-derived signaling