2-CHLORO-N(6)-CYCLOPENTYLADENOSINE (CCPA), AN ADENOSINE-A(1) RECEPTOR AGONIST, SUPPRESSES ETHANOL WITHDRAWAL SYNDROME IN RATS

The ability of 2-chloro-N6-cyclopentyladenosine (CCPA) to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by intragastric administrations of ethanol (12-18 g/kg daily for 6 days). CCPA administered 24 hr after the last ethanol dose produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically induced seizures, an effect prevented by the A1 receptor antagonist 8-cyclopentyl-1,3-diproplyxanthine (DPCPX).