Protocol and pilot study for a systematic review on genotoxicity of RF-EMF in vitro

The objective of this study was to develop a protocol for a systematic review of in vitro studies on genotoxicity of radiofrequency electromagnetic fields (EMF). We followed the guidelines developed by the National Toxicology Program-Office of Health Assessment and Translation (NTP-OHAT), adapted to the peculiarities of in vitro investigations and EMF exposures. We piloted our approach on a subset of studies. To our knowledge, this is the first protocol for systematic reviews of mechanistic studies with an in vitro exposure regime, with predefined inclusion criteria and risk of bias assessment.