ENMET: Endothelial cell metabolism mathematical mode

Endothelial cells have central role in controlling blood vessels homeostasis, secreting vasodilator (Nitric Oxide, NO) and vasoconstrictor (Endothelin-1, ET-1) molecules, in response to various shear-stress levels due to blood flow. ENMET (Endothelial cell METabolism) is mathematical model that mimics completely the principal metabolic pathways in endothelial cell, connecting mechanical-stimuli responses (Et-1 and NO production) to main biochemical reactions. It is based on a set of nonlinear differential equations, implemented in Simulink® , based on the cellular energetic state. The validation phase is based on experiments performed in a dynamic culture chamber where cell culture is exposed to a laminar flow that generates a well controlled shear stress. © 2009 IEEE.